个人简介

曾珊，医学博士，副主任医师，硕士研究生导师，2017年于中山大学内科学博士毕业后一直从事风湿病学临床工作及研究，目前在国内外重要刊物发表文章17篇，其中以第一作者、通讯作者发表SCI收录论文13篇，主持包括国自然基金等各级基金课题3项。荣获暨南大学“优秀青年教师”、医院“科研工作先进个人”“医疗护理工作先进个人”等系列称号。研究方向：eEF2K在类风湿关节炎疾病发生发展中的作用机制研究，类风湿关节炎中与T细胞相关的生物标志物研究，类风湿关节炎先天免疫基因的分析及潜在治疗作用，BRD4蛋白调控浆细胞分化及对系统性红斑狼疮的治疗潜力。擅长疾病：类风湿关节炎、系统性红斑狼疮、强直性脊柱炎、痛风、骨关节炎、骨质疏松症、系统性硬化、干燥综合征、多发性肌炎、皮肌炎、成人Still病、幼年特发性关节炎、银屑病性关节炎、混合结缔组织病、抗磷脂抗体综合征、白塞病、血管炎等各类风湿病的规范化诊治、研究和教学。

学术任职

广东省精准医学应用学会高尿酸血症与痛风分会秘书

广东省精准医学应用学会自身免疫病分会委员

广东省老年保健协会风湿免疫专委会第一届委员

广东省临床医学学会风湿免疫专委会第一届青年委员

广东省医疗行业协会风湿免疫分会第一届青年委员

广东省保健协议风湿免疫分会第一届委员

广东省中西医结合学会风湿病专业委员会委员

主研方向

eEF2K在类风湿关节炎疾病发生发展中的作用机制研究，类风湿关节炎中与T细胞相关的生物标志物研究，类风湿关节炎先天免疫基因的分析及潜在治疗作用，BRD4调控外周浆细胞分化及对系统性红斑狼疮的治疗潜力。

获奖情况

暨南大学“优秀青年教师”培养支持对象；2019年获评暨南大学附属第一医院“科研工作先进个人”、“医疗护理工作先进个人”。

学术论著

1.        Nan Li¹,Shulin Chen^2,3, Weiqing Deng⁴, Zhaohui Gong^2,5, Yu Guo^1,7, Shan Zeng^6,7, and Qiang Xu2,3,7 Kaempferol Attenuates Gouty Arthritis by Regulating the Balance of Th17/Treg Cells and Secretion of IL-17. 14 June 2023.

2.        Zhenyu Zhao^1† , Jie Ren^2† , Siping Xie^3†, Longchun Zou⁴ , Qianyue Zhao⁵, Shan Zeng^2* and Dingsheng Zha^1*. Identification of biomarkers associated with CD8+ T cells in rheumatoid arthritis and their pan-cancer analysis. Frontiers In Immunology . 24 NOV 2022.

3.        Nan Li ^{a, 1}, Xiaojuan Li ^{a, 1}, Lijuan Deng ^{a, 1}, Haixin Yang ^a, Zhaohui Gong ^b, Qiang Wang ^c, Dongmei Pan ^{d, ⁎}, Shan Zeng^{e, ⁎}, Jiaxu Chen^{a, ⁎}. 6-Shogaol inhibits the proliferation, apoptosis, and migration of rheumatoid arthritis fibroblast-like synoviocytes via the PI3K/AKT/NF-κB pathway。Phytomedicine. NOV 2022.

4.        Shan Zeng^a,b,1, Qian Qiu^a,1, Yi Zhou^b,1, Youjun Xiao^a, Jingnan Wang^a, Ruiru Li^a, Siqi Xu^a, Maohua Shi^a, Cuicui Wang^c, Yu Kuang^a, Minxi Lao^a, Xiaoyan Cai^{c, *}, Liuqin Liang^{a, *} Hanshi Xu^a,*.The suppression of Brd4 inhibits peripheral plasma cell differentiation and exhibits therapeutic potential for systemic lupus erythematosus. International Immunopharmacology .FEB 2022.

5.        Zhenyu Zhao^1†, Shaojie He^1†, Sheng Tang^1†, Xiaofeng Lai¹, Jie Ren², XinCheng Yu¹, Jinhua Lin¹, Mohan Wang³, Mariya M. El Akkawi⁴, Shan Zeng^2* and Dingsheng Zha^1*. CLP1 is a Prognosis-Related Biomarker and Correlates With Immune Infiltrates in Rheumatoid Arthritis. Frontiers In Pharmacology , 01 June 2022.

6.        ZhenYu Zhao^1†, ShaoJie He^2†, XinCheng Yu^1†, XiaoFeng Lai^1†, Sheng Tang³, El Akkawi Mariya M. ⁴, MoHan Wang ¹, Hai Yan ⁵, XingQi Huang ⁶, Shan Zeng ^7* and DingSheng Zha^1*. Analysis and Experimental Validation of Rheumatoid Arthritis Innate Immunity Gene CYFIP2 and Pan-Cancer. Frontiers In Immunology , 11 JUL 2022.

7.        M Huang^*，K Wu^*，S Zeng^*，W Liu，T Cui，Z Chen，L Lin，D Chen，H Ouyang. Punicalagin Inhibited Inflammation and Migration of Fibroblast-Like Synoviocytes Through NF-κB Pathway in the Experimental Study of Rheumatoid Arthritis. Journal of Inflammation Research, 2021.S

8.        Zeng Shan^#, Wang Kefeng^#, Huang Mingcheng^#, Ou Qian, Xiao Youjun, Shi Maohua，Zou Yaoyao, Yang Xiuyan, Xu Hanshi, Liang Liuqin^*, Halofuginone inhibits TNF-α-induced the migration and proliferation of fibroblast-like synoviocytes from rheumatoid arthritis patients, International Immunopharmacology, 2017, 43: 187 –194.

9.        Chen Dongying^#, Zeng Shan^#, Huang Mingcheng^#, Xu Hanshi, Liang Liuqin^*, Yang Xiuyan, Role of Protein Arginine Methyltransferase 5(PRMT5) in Inflammation and Migration of fibroblast-like synoviocytes in rheumatoid arthritis. Journal of Cellular and Molecular Medicine, 2017, 21(4): 781-790.

10.    Huang Mingcheng^#, Zeng Shan^#, Zou Yaoyao^#, Shi Maohua, Qiu Qian, Xiao Youjun, Chen Guoqiang, Yang Xiuyan, Liang Liuqin, Xu Hanshi^*, The suppression of bromodomain and extra-terminal domain inhibits vascular inflammation by blocking NF-κB and MAPK activation. British Journal of Pharmacology, 2017, 174(1): 101 -115.

11.    Huang Mingcheng^#, Zeng Shan^#, Qiu Qian, Xiao Youjun, Shi Maohua, Zou Yaoyao, Yang Xiuyan, Xu Hanshi, Liang Liuqin^*, Niclosamide induces apoptosis in human rheumatoid arthritis fibroblast-like synoviocytes, International Immunopharmacology, 2016, 31: 45-9. (IF:2.956).

12.    Zou Yaoyao^#, Zeng Shan^#, Huang Mingcheng^#, Qiu Qian, Xiao Youjun, Shi Maohua, Zhan Zhongping, Liang Liuqin, Yang Xiuyan, Xu Hanshi^*, Inhibition of 6-phosphofructo-2-kinase suppresses fibroblast-like synoviocytes- mediated synovial inflammation and joint destruction in rheumatoid arthritis, British Journal of Pharmacology, 2017, 174(9): 893-908.