个人简介

2013.7 -至今  暨南大学 粤港澳中枢神经再生研究院/第一临床医学院            副研究员

             承担本科生、硕士研究生、博士研究生《高级神经生物学》、《神经生物学》等课程教学

2011.3 -2013.6 美国南加州大学Keck神经遗传研究所                            博士后

2002.8 -2010.6 暨南大学 基础医学院/第一临床医学院             硕士研究生/博士研究生

学术任职

中国神经科学学会儿童认知与脑功能障碍分会委员，美国神经科学学会会员，国家自然科学基金等基金项目函评专家，Molecular Neurobiology、Frontiers in Aging Neuroscience等期刊受邀审稿人。教育部中枢神经再生国际合作联合实验室PI、副研究员，暨南大学第一临床医学院临床神经科学研究所副研究员。

主研方向

临床诊疗相关课题研究方向：

儿童多动症、自闭症等神经发育疾病的队列分析、遗传筛查及基于类脑组织器官和模式动物模型的诊疗机制探索。

课题：

· 国家自然科学基金（面上项目，自闭症患者SHANK2突变对神经元结构与功能发育的影响及其基因编辑修复研究，81771222）

· 国家自然科学基金（青年项目，SHANK3基因表达下调对神经干细胞发育的功能基因组学影响，31400922，）

· 国家重点研发计划（神经疾病大动物模型的建立及干细胞治疗评价，2017YFA0105102）

· 广东省自然科学基金（Moesin基因表达下调影响小鼠社交行为的机制探索及运动干预研究，2019A151501 1316）

· 广州市科创委项目基金（自闭症患者来源诱导多能干细胞神经发育异常的功能基因组学研究，201804010212）

· 教育部留学回国人员科研启动基金（全基因组测序技术应用于自闭症复杂家系候选基因筛选的初步研究，216 14331）

获奖情况

暨南大学优秀青年教师

学术论著

·                   Shu-Ting Chen#, Wan-Jing Lai#, Wei-Jia Zhang, Qing-Pei Chen, Li-Bing Zhou, Kwok-Fai So, Ling-Ling Shi*. Insulin-like growth factor 1 partially rescues early developmental defects caused by SHANK2 knockdown in human neurons. Neural Regeneration Research . 2020,15(12):2335-2343. [Editor’s Pick 2021 ]

·                   Xiaokuang Ma#, Ke Chen, Yuehua Cui, Guanqun Huang, Antoine Nehme, Le Zhang, Handong Li, Jing Wei, Katerina Liong, Qiang Liu, Lingling Shi*, Jie Wu*, Shenfeng Qiu*. Depletion of microglia in developing cortical circuits reveals its critical role in glutamatergic synapse development, functional connectivity, and critical period plasticity. Journal of Neuroscience research. 2020,98(10):1968-1986.

·                   Aimei Liu#, Sai Kang, Panpan Yu, Lingling Shi*, Libing Zhou*. Transplantation of human urine-derived neural progenitor cells after spinal cord injury in rats. Neuroscience Letters.2020,735(14) 135201.

·                   Guanqun Huang, Jiajun Zheng,  Xiaoxia Chen,   Zhuoran Xu,  Abolfazl Doostparast Torshizi,  Siyi Gong,  Sai Kang,  Xiaokuang Ma,  Jiandong Yu,  Libing Zhou,  Shenfeng Qiu and  Kai Wang， Lingling Shi* .Uncovering the functional link between SHANK3 deletions and deficiency in neurodevelopment using iPSC-derived human neurons. Frontiers in Neuroanatomy. 2019,13,13(23):1-13.

·                   Sai Kang, Xiaoxia Chen, Siyi Gong, Panpan Yu, SukYu Yau, Zhenghui Su, Libing Zhou, Jiandong Yu*, Guangjin Pan* & Lingling Shi*. Characteristic analyses of a neural differentiation model from iPSC-derived neuron according to morphology, physiology, and global gene expression pattern. Scientific Reports. 2017,7(1):12233.

·                   Lingling Shi Yunfei Guo, Chengliang Dong, John Huddleston, Hui Yang, Xiaolu Han, Aisi Fu, Quan Li, Na Li, Siyi Gong, Katherine E. Lintner, Qiong Ding, Zou Wang, Jiang Hu, Depeng Wang, Feng Wang, Lin Wang, Gholson J. Lyon, Yongtao Guan, Yufeng Shen, Oleg V. Evgrafov, James A. Knowles, Francoise Thibaud-Nissen, Valerie Schneider, Chack-Yung Yu, Libing Zhou1,Evan E. Eichler, Kwok-Fai So, & Kai Wang. Long-read sequencing and de novo assembly of a Chinese genome. NATURE COMMUNICATIONS.  2016, 7:12065.

·                   Lingling Shi, Bingxiao Li, Yonglan Huang, Xueying Ling, Tianyun Liu, Gholson J Lyon, Anding Xu, Kai Wang.“Genotype-first” approaches on a curious case of idiopathic progressive cognitive decline. BMC Med Genomics. 2014, 3;7(1):66.

·                   Ling-ling Shi, Xiao Chang, Peilin Zhang, Macello Coba, Wange Lu, Kai Wang. The functional genetic link of NLGN4X knockdown and neurodevelopment in neural stem cells. Human Molecular Genetics. 2013, 22(18):3749-60.

·                    Ling-ling Shi, Xu Zhang, Ryan Golhar, Frederick G Otieno, Mingze He, Cuiping Hou, Cecelia Kim, Brendan Keating, Kai Wang, Hakon Hakonarson. Whole-genome sequencing in an autism multiplex family. Molecular Autism 2013, 4:8 .